Microwave-assisted facile synthesis of mono-dispersed Ba/Ho co-doped nanohydroxyapatite for potential application as binary CT imaging contrast agent

作者：Zheng, Xiaoke; Wang, Shanling; Wu, Lan^*; Hou, Xiandeng^*

来源：Microchemical Journal, 2018, 141: 330-336.

DOI：10.1016/j.microc.2018.05.044

• Microwave assisted synthesis
• Contrast agent
• CT imaging
• Ba-doped
• Ho-doped
• Nano-hydroxyapatite

It is appealing to develop a facile way to prepare a binary CT contrast agent with good biocompatibility and CT contrast efficiency for potential clinical applications. In this work, a novel binary CT contrast agent based on the biocompatible nano-hydroxyapatite (nHAp, the main inorganic component of human bone and teeth) was prepared facilely and rapidly through doping two kinds of CT contrast ions (Ba2+ and Ho3+) into the nHAp host via microwave-assisted synthesis. The Ba/Ho co-doped nHAp with pure nHAp phase composition and good mono-dispersion was obtained simply with microwave heating for 30 min. The as prepared CT contrast agent is very promising as a novel binary CT contrast agent for CT imaging.

• 出版日期2018-9
• 单位四川大学