A parametric approach to the probability of plaque rupture based on lumen geometry in coronary arteries using design of experiments

作者：Lee Wookjin; Cho Seong Wook^*

来源：Journal of Mechanical Science and Technology, 2018, 32(4): 1661-1666.

DOI：10.1007/s12206-018-0321-7

• Coronary artery
• Design of experiments
• Finite element analysis
• Plaque rupture

Two-dimensional numerical models of arterial plaque are used to determine the effects of the geometrical characteristics of the lumen on the stress gradient and stress distribution. Three parameters with three levels that form the plaque lumen, stenosis rate by diameter, eccentricity, and ellipticity, were analyzed based on experimental design. A review of 27 cases confirmed that the stress and stress gradient tended to increase with a decreasing stenosis rate by diameter, and the eccentricity and ellipticity ratio also increased. Eccentricity had the greatest influence on the mechanical behavior of the plaque, and it was confirmed that even the same types of plaques varied in magnitude of influence depending on the geometrical characteristics of the lumen.

• 出版日期2018-4