科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: A high degree of co-morbidity exists between methamphetamine (MA) addiction and alcohol use disorders and both sequential and simultaneous MA-alcohol mixing increases risk for co-abuse. As little pre-clinical work has focused on the biobehavioral interactions between MA and alcohol within the context of drug taking behavior, we employed simple murine models of voluntary oral drug consumption to examine how prior histories of either MA- or alcohol-taking influence the intake of the other drug. Methods: In one study, mice with a 10-day history of binge alcohol-drinking {5,10, 20 and 40% (v/v); 2 h/day] were trained to self-administer oral MA in an operant-conditioning paradigm (10-40 mg/L). In a second study, mice with a 10-day history of limited-access oral MA-drinking (5, 10, 20 and 40 mg/L; 2 h/day) were presented with alcohol (5-40% v/v; 2 h/day) and then a choice between solutions of 20% alcohol, 10 mg/L MA or their mix. Results: Under operant-conditioning procedures, alcohol-drinking mice exhibited less MA reinforcement overall, than water controls. However, when drug availability was not behaviorally-contingent, alcohol-drinking mice consumed more MA and exhibited greater preference for the 10 mg/L MA solution than drug-naive and combination drug-experienced mice. Conversely, prior MA-drinking history increased alcohol intake across a range of alcohol concentrations. Discussion: These exploratory studies indicate the feasibility of employing procedurally simple murine models of sequential and simultaneous oral MA-alcohol mixing of relevance to advancing our biobehavioral understanding of MA-alcohol co-abuse.
- 出版日期2017-8-1
