AID-mediated somatic hypermutation for generation of viral envelope protein diversity in patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies

作者：Suslov Konstantin V^*

来源：Immunology Letters, 2010, 128(1): 86-87.

DOI：10.1016/j.imlet.2009.11.004

• Activation-induced cytidine deaminase
• Somatic hypermutation
• B cells
• HIV-1
• AIDS
• Envelope protein
• gp120
• R5-X4 HIV-1 switch
• Vaccine
• Neutralizing antibodies

The somatic hypermutation (SHM) hypothesis for R5-X4 HIV-1 switching has recently received experimental support. AID-mediated SHM in B cell lines can be used to generate patient's HIV-1 envelope protein diversity in vitro for subsequent vaccination of HIV-1-infected patient at the beginning of asymptomatic period with a resulting mixture of mutant envelope proteins. Suggested approach, which represents a vaccination against R5-X4 HIV-1 switching, might open possibilities for creation of patient-specific therapeutic HIV vaccines based on induction of neutralizing antibodies.

• 出版日期2010-1-18