Nonsteroidal Anti-Inflammatory Drug Use and Endurance During Running in Male Long-Distance Runners

作者：Da Silva Eduardo^*; Pinto Ronei S; Cadore Eduardo L; Kruel Luiz F

来源：Journal of Athletic Training, 2015, 50(3): 295-302.

DOI：10.4085/1062-6050-49.5.04

• NSAIDs
• ibuprofen
• muscle pain
• fatigue
• exercise

Context: The effect of ibuprofen on pain tolerance during exercise is controversial, and its effects on endurance performance have been poorly investigated.
Objective: To investigate the effect of prophylactic administration of the nonsteroidal anti-inflammatory drug ibuprofen on the time until the self-report of fatigue (t(lim)) in runners with exercise-induced muscle damage.
Design: Randomized controlled clinical trial.
Setting: Laboratory.
Patients or Other Participants: Twenty healthy male long-distance runners (age = 18.8 +/- 0.4 years, maximal oxygen consumption = 55.5 +/- 5.9 mL.kg(-1).min(-1)).
Intervention(s): Participants were assigned to 2 groups (ibuprofen group = 10, placebo group = 10) to perform t(lim) trials (speed corresponded to their previously determined second-ventilatory thresholds) 48 hours before and 48 hours after the induction of a lower limb muscle-damage protocol (isokinetic dynamometry). One hour before the second t(lim) trial, the ibuprofen group received 1.2 g ibuprofen, and the placebo group received lactose orally.
Main Outcome Measure(s): Time until self-reported fatigue, heart rate, respiratory quotient, oxygen consumption, and perceived exertion were recorded during each t(lim) test.
Results: Both groups reported increases in muscle pain in the knee extensors and flexors 48 hours after the muscle-damage protocol. We observed a reduction in the endurance performance of both groups (P < .01) but no difference between groups (P = .55).
Conclusions: Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners.

• 出版日期2015-3