Association of Fc gamma RIIIa-158V/F with systemic lupus erythematosus in a Chinese population

作者：Dai, Min; Zhou, Zhenyuan; Wang, Xiaodong; Qian, Xiaoxia; Huang, Xinfang^*

来源：International Journal of Rheumatic Diseases, 2013, 16(6): 685-691.

DOI：10.1111/1756-185X.12176

• Chinese
• Fc gamma receptor
• lupus nephritis
• systemic lupus erythematosus

Aim: It has long been a controversy that polymorphisms in Fc gamma RIIIa (CD16A) receptors are associated with systemic lupus erythematosus (SLE). We aimed to verify the association of Fc gamma RIIIa polymorphisms with SLE in a large Chinese population.
Methods: We genotyped Fc gamma RIIIa-158V/F (rs396991) using a pyro-sequencing assay (PSQ 96MA) in a total of 732 individuals with SLE (390 lupus nephritis and 342 non-lupus nephritis) and 886 controls. Meta-analysis was used to examine the association of the Fc gamma RIIIa-F158 allele with SLE and lupus nephritis with RevMan 5.
Results: The allele frequencies of Fc gamma RIIIa-F158 were significantly increased in SLE (OR 1.293, 95% CI 1.111-1.505, P = 0.0009). There was significant skewing in the distribution of Fc gamma RIIIa genotypes between SLE patients and controls (P = 0.0026 for 158 F/F vs. 158F/V and 158V/V, OR 1.604, 95% CI 1.089-2.361). Serositis was more common in patients with the Fc gamma RIIIa-F158 allele and Fc gamma RIIIa-F/F genotype, and low complement was more common in patients with the Fc gamma RIIIa-F/F genotype. There was no skewing in the distribution of Fc gamma RIIIa genotypes in the lupus nephritis group. No association was found for the frequencies of the FccRIIIa-F158 allele and 158F/F genotype compared with the V158 allele and F/V plus V/V genotypes, respectively, between lupus nephritis and SLE without nephritis patients in a meta-analysis of 11 Asian studies.
Conclusion: Our results suggest that the low-binding allele Fc gamma RIIIa-158F is one of the risk factors for SLE in the Chinese population.

• 出版日期2013-12
• 单位上海交通大学