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摘要
Background: The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis. Methods: Eighteen 4 T1 homograft tumor models were divided into control, paclitaxel monotherapy and paclitaxel and bevacizumab combination therapy groups (n = 6) that underwent multi-b-value DWI, DCE-MRI and texture analysis before and 15 days after treatment. Results: After treatment, the tumors in the control group were significantly larger than those in the combination group (P = 0.018). In multi-b-value DWI, the ADC(slow) obviously increased in the combination group compared to that in the others (P < 0.01). The f increased in the control and paclitaxel groups, but the combination group showed a significant decrease versus the others (P < 0.02). Additionally, in DCE-MRI, the decreasing K-trans showed an evident difference between the combination and control groups (P = 0.003) due to the latter's increasing K-trans. The intra-group comparisons of tumor texture in pre-, mid-and post-treatments showed that the entropy had all significantly increased in all groups (P < 0.01, SSF = 0-6), though the MPP, mean and SD increased only in the combination group (P-MPP,P- mean, SD < 0.05, SSF = 4-6). Moreover, the inter-group comparisons revealed that the mean and MPP exhibited significant differences after treatment (P-mean,P- MPP < 0.05, SSF = 0-3). Conclusion: All these results suggest some strong correlations among DWI, DCE and texture analysis, which are beneficial for further study and clinical research.
- 出版日期2018-8-20
- 单位北京协和医学院; 中国医学科学院北京协和医院; 中国医学科学院基础医学研究所
