Dasatinib-induced immune mediated-thrombotic thrombocytopenic purpura

作者：Demirsoy Esra Terzi^*; Mehtap Ozgur; Atesoglu Elif Birtas; Tarkun Pinar; Eren Necmi; Geduk Ayfer; Hacihanefioglu Abdullah

来源：Transfusion and Apheresis Science, 2018, 57(2): 222-224.

DOI：10.1016/j.transci.2018.02.003

• Dasatinib
• Thrombotic thromboytopenic purpura
• Plasma exchange
• Side effect

Most commonly seen side effects with Tyrosine kinase inhibitors (TKI's) are hematologic toxicities. Besides, with dasatinib autoimmune side effects can be seen. Thrombotic thrombocytopenic purpura (TTP) is a life-threatening disease that can be related to various causes mainly autoimmune disorders or antineoplastic drugs. Few cases of TKI associated secondary thrombotic microangiopathies (TMA) have been reported in literature. Most of cases were diagnosed as hemolytic uremic syndrome (HUS) rather than TTP. Herein, we describe a 37-year-old CML patient who was diagnosed as immune-mediated TTP related to dasatinib.

• 出版日期2018-4