Nutrition and L and K-enteroendocrine cells

作者：Gutierrez Aguilar Ruth; Woods Stephen C^*

来源：Current Opinion in Endocrinology Diabetes and Obesity, 2011, 18(1): 35-41.

DOI：10.1097/MED.0b013e32834190b5

• glucagon
• glucagon-like peptide-1
• glucose-dependent insulinotropic polypeptide
• incretin
• oxyntomodulin

Purpose of review
The review highlights the influence of nutrients over the secretion of several hormones produced by enteroendocrine cells in the gastrointestinal tract that secrete incretin hormones. These hormones influence glucose homeostasis; food intake; gastric, pancreatic and hepatic secretions; and gastric and intestinal motility, and these aspects are summarized in this review.
Recent findings
This study provides an overview of recent advances in our understanding of the physiology of the incretins, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), as well as of oxyntomodulin. A better understanding of the secretion and action of these hormones at their receptors was made possible by new techniques that allow investigation of individual enteroendocrine cells.
Summary
The better understanding of the function of the gastrointestinal incretin hormones and their implications for improving glucose homeostasis and perhaps influencing food intake and appetite as well, new research in this area will help combat metabolic diseases such as type 2 diabetes and obesity.

• 出版日期2011-2