Preparation and conformational study of CF3-containing enkephalin-derived oligopeptide

作者：Kitamoto Takamasa; Marubayashi Shunsuke; Yamazaki Takashi^*

来源：Tetrahedron, 2008, 64(8): 1888-1894.

DOI：10.1016/j.tet.2007.11.085

• fluorinated amino acid
• peptides
• conformations
• NOESY spectra

Incorporation of (2S,3S)-4,4,4-trifluorothreonine (F-3-Thr) instead of Thr in the enkephalin-derived hexapeptide led to the apparent conformational alteration due to the strong electron-withdrawing effect of the trifluoromethyl group by comparison with the original compound on the basis of their various NMR measurements.

• 出版日期2008-2-18