A Weinreb amide approach to the synthesis of trifluoromethylketones

作者：Rudzinski DiAndra M; Kelly Christopher B; Leadbeater Nicholas E^*

来源：Chemical communications, 2012, 48(77): 9610-9612.

DOI：10.1039/c2cc35037h

A novel route to access trifluoromethylketones (TFMKs) from Weinreb amides is reported. This represents the first documented case of the Ruppert-Prakash reagent (TMS-CF3) reacting in a constructive manner with an amide and enables synthesis of TMFKs without risk of over-trifluoromethylation.

• 出版日期2012