Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection

作者：Muenchhoff Maximilian; Adland Emily; Karimanzira Owen; Crowther Carol; Pace Matthew; Csala Anna; Leitman Ellen; Moonsamy Angeline; McGregor Callum; Hurst Jacob; Groll Andreas; Mori Masahiko; Sinmyee Smruti; Thobakgale Christina; Tudor Williams Gareth; Prendergast Andrew J; Kloverpris Henrik; Roider Julia; Leslie Alasdair; Shingadia Delane; Brits Thea; Daniels Samantha; Frater John; Willberg Christian B; Walker Bruce D; Ndung'u Thumbi; Jooste Pieter; Moore Penny L

来源：Science Translational Medicine, 2016, 8(358): 358ra125.

DOI：10.1126/scitranslmed.aag1048

Disease-free infection in HIV-infected adults is associated with human leukocyte antigen-mediated suppression of viremia, whereas in the sooty mangabey and other healthy natural hosts of simian immunodeficiency virus (SIV), viral replication continues unabated. To better understand factors preventing HIV disease, we investigated pediatric infection, where AIDS typically develops more rapidly than in adults. Among 170 nonprogressing antiretroviral therapy-naive children aged >5 years maintaining normal-for-age CD4 T cell counts, immune activation levels were low despite high viremia (median, 26,000 copies/ml). Potent, broadly neutralizing antibody responses in most of the subjects and strong virus-specific T cell activity were present but did not drive pediatric nonprogression. However, reduced CCR5 expression and low HIV infection in long-lived central memory CD4 T cells were observed in pediatric nonprogressors. These children therefore express two cardinal immunological features of nonpathogenic SIV infection in sooty mangabeys-low immune activation despite high viremia and low CCR5 expression on long-lived central memory CD4 T cells-suggesting closer similarities with nonpathogenetic mechanisms evolved over thousands of years in natural SIV hosts than those operating in HIV-infected adults.

• 出版日期2016-9-28