Angioimmunoblastic T-cell lymphoma mice model

作者：Sato Fumihiko; Ishida Takashi^*; Ito Asahi; Mori Fumiko; Masaki Ayako; Takino Hisashi; Narita Tomoko; Ri Masaki; Kusumoto Shigeru; Suzuki Susumu; Komatsu Hirokazu; Niimi Akio; Ueda Ryuzo; Inagaki Hiroshi; Iida Shinsuke

来源：Leukemia Research, 2013, 37(1): 21-27.

DOI：10.1016/j.leukres.2012.09.009

• Angioimmunoblastic T-cell lymphoma
• Follicular helper T cell
• BCL6
• PD1
• NOG mice
• Tumor microenvironment

We established an angioimmunoblastic T-cell lymphoma (AITL) mouse model using NOD/Shi-scid, IL-2R gamma(null) mice as recipients. The immunohistological findings of the AITL mice were almost identical to those of patients with AITL. In addition, substantial amounts of human immunoglobulin G/A/M were detected in the sera of the AITL mice. This result indicates that AITL tumor cells helped antibody production by B cells or plasma cells. This is the first report of reconstituting follicular helper T (TFH) function in AITL cells in an experimental model, and this is consistent with the theory that TFH cell is the cell of origin of AITL tumor cells.

• 出版日期2013-1