Genetic association of DRD2 polymorphisms with anxiety scores among alcohol-dependent patients

作者：Joe Keun Ho; Kim Dai Jin^*; Park Byung Lae; Yoon Sujung; Lee Hae Kook; Kim Tae Suk; Cheon Young Hoon; Gwon Do Hoon; Cho Sung Nam; Lee Hye Won; NamGung Suk; Shin Hyoung Doo

来源：Biochemical and Biophysical Research Communications, 2008, 371(4): 591-595.

DOI：10.1016/j.bbrc.2008.02.076

• DRD2
• polymorphism
• alcoholism
• STAI-S
• STAI-T

The dopaminergic neurotransmission system is one of the major factors in development of alcoholism and also contributes to anxiety and depression. In this study, the associations of the dopamine receptor type 2 (DRD2) polymorphisms with the symptoms of anxiety were analyzed. A total of 573 alcoholics and 273 controls were enrolled in the study from the Korean population. Five DRD2 SNPs, including -32869 A>G, -32768 insdel C, +11890 C>G, +11915 C>T, and +32806 C>T, were genotyped using a TaqMan assay and analyzed with various alcoholic phenotypes. Although no DRD2 polymorphisms were associated with the risk of alcoholism, +32806 C>T and Block2-ht1 showed associations (in dominant models) with both the state anxiety level scale (STAI-S) and the trait anxiety level scale (STAI-T) (P = 0.004 and P = 0.003, and P = 0.01 and P = 0.005, respectively). In addition, the -32768 insdel C also showed positive association with both anxiety level scales in recessive models (P = 0.01 and P = 0.02, respectively).

• 出版日期2008-7-11