Elucidation of an Iterative Process of Carbon-Carbon Bond Formation of Prebiotic Significance

作者：Loison Aurelie; Dubant Stephane; Adam Pierre; Albrecht Pierre^*

来源：Astrobiology, 2010, 10(10): 973-988.

DOI：10.1089/ast.2009.0441

• Prebiotic synthesis
• Hydrothermal vents
• Thiols
• Sulfides
• Nickel
• Aldehydes
• Carbon monoxide
• Transition metals
• C-C bond formation

Laboratory experiments carried out under plausible prebiotic conditions (under conditions that might have occurred at primitive deep-sea hydrothermal vents) in water and involving constituents that occur in the vicinity of submarine hydrothermal vents (e.g., CO, H(2)S, NiS) have disclosed an iterative Ni-catalyzed pathway of C-C bond formation. This pathway leads from CO to various organic molecules that comprise, notably, thiols, alkylmono- and disulfides, carboxylic acids, and related thioesters containing up to four carbon atoms. Furthermore, similar experiments with organic compounds containing various functionalities, such as thiols, carboxylic acids, thioesters, and alcohols, gave clues to the mechanisms of this novel synthetic process in which reduced metal species, in particular Ni(0), appear to be the key catalysts. Moreover, the formation of aldehydes (and ketones) as labile intermediates via a hydroformylation-related process proved to be at the core of the chain elongation process. Since this process can potentially lead to organic compounds with any chain length, it could have played a significant role in the prebiotic formation of lipidic amphiphilic molecules such as fatty acids, potential precursors of membrane constituents.

• 出版日期2010-12