A New Type of Colored Alumina/glass Composite Biological Safety Assessment - Cell Toxicity and Hemolysis Tests

作者：Deng, Bin^*; Lu, Huai-Xiu; Shao, Long-quan; Yi, Yuan-Fu; Liu, Jie; Hou, Kang-Lin; Zhang, Wei-Wei; Wen, Ning

来源：1st Annual Meeting on Testing and Evaluation of Inorganic Materials, Nanchang, PEOPLES R CHINA, 2010-04-28 To 2010-04-30.

DOI：10.4028/www.scientific.net/AMR.177.459

• Alumina/glass composite
• Hemolysis test
• Cell toxicity test

Objective: to evaluate the biological safety of a colored alumina/glass composite in terms of cytotoxicity and hemolytic ability. Methods: the cytotoxicity of an alumina/glass composite was evaluated with molecular filtration method. Cytotoxicity by spectrophotometric responses of test material and responses of a fresh rabbit red blood anticoagulant solution was determined by spectrophotometer. Results: cell-coated filter paper in contact with the test material showed the appearance of intracellular blue dye as the same staining density as in control samples, leading to a toxicity rating of 0. Colored alumina/glass composite assayed at <5% hemolysis. Conclusion: colored alumina/glass composite materials showed low cytotoxicity and non-acute hemolytic rates, representing overall good biological safety under these conditions.

• 出版日期2011
• 单位中国人民解放军总医院; 中国人民解放军海军总医院