Add-on Therapy of EPA Reduces Oxidative Stress and Inhibits the Progression of Aortic Stiffness in Patients with Coronary Artery Disease and Statin Therapy: A Randomized Controlled Study

作者：Takaki Akira; Umemoto Seiji^*; Ono Kaoru; Seki Kouzaburo; Ryoke Tsutomu; Fujii Akihisa; Itagaki Tatsunori; Harada Masahiko; Tanaka Masakazu; Yonezawa Takahito; Ogawa Hiroshi; Matsuzaki Masunori

来源：Journal of Atherosclerosis and Thrombosis, 2011, 18(10): 857-866.

DOI：10.5551/jat.7260

• Eicosapentaenoic acid
• Oxidative stress
• Arterial stiffness
• Coronary artery disease

Aim: We examined the anti-oxidant mechanisms of combined therapy of eicosapentaenoic acid (EPA) plus statin on the progression of atherosclerosis.
Methods: Patients receiving statin therapy for dyslipidemia and with coronary artery disease (CAD) were assigned randomly in an open-label manner to the EPA (1,800 mg/day) -plus-statin group (n = 25; combined-therapy group) or to the statin-only group (n = 25), and followed for 48 weeks. At baseline and 48 weeks after enrollment, oxidative stress, brachial-ankle pulse wave velocity (baPWV) and stiffness parameter beta-index of the carotid were measured.
Results: The lipid profile remained unchanged throughout the study. Although the median value of baPWV increased more in the statin-only group than in the combined-therapy group, this difference was not significant (p = 0.29); however, a decrease in baPWV was associated with combined-therapy treatment by multiple regression analysis adjusted for age and mean blood pressure (p = 0.04). In addition, the beta-index of the carotid was lower in the combined-therapy group than in the statin-only group (p = 0.02). Furthermore, although the difference in the reduction of the urinary concentration of 8-isoprostane between the two groups did not reach statistical significance, this concentration was significantly lower in the combined-therapy group with higher baseline levels (>= 183 pg/mL . Cr) of urinary 8-isoprostane (p = 0.004).
Conclusions: EPA may reduce oxidative stress and inhibit the progression of arterial stiffness more efficiently than statin-only therapy in patients with dyslipidemia and CAD.

• 出版日期2011