Aminothiocarbamate-Catalyzed Asymmetric Bromolactonization of 1,2-Disubstituted Olefinic Acids

作者：Tan Chong Kiat; Zhou Ling; Yeung Ying Yeung^*

来源：Organic Letters, 2011, 13(10): 2738-2741.

DOI：10.1021/ol200840e

An efficient and enantioselective bromolactonization of 1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst has been developed, resulting In the formation of delta-lactones containing two chiral centers with up to 99% yield, 95% ee.

• 出版日期2011-5-20