Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents

作者：Rizk Ola H; Shaaban Omaima G^*; El Ashmawy Ibrahim M

来源：European Journal of Medicinal Chemistry, 2012, 55: 85-93.

DOI：10.1016/j.ejmech.2012.07.007

• Synthesis
• Thienopyrimidines
• Fused thienopyrimidines
• Anti-inflammatory activity

Some new substituted thienopyrimidine derivatives comprising thioxo, thioalkyl and pyrazolyl derivatives as well as fused thienotriazolopyrimidine and thienopyrimidinotriazine ring systems were prepared from 3-benzyl-2-hydrazino-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide 4. The designed compounds were evaluated for their anti-inflammatory activity. Compounds 4, 9, 10 and 13 showed the highest anti-inflammatory effect compared with the reference drug diclofenac sodium.

• 出版日期2012-9