Neurodevelopmental outcomes after a brief exposure to the inhaled anesthetic sevoflurane in young children undergoing palatoplasty

作者：Lv, Xiang; Lu, Yi; Tang, Yi-Wen; Jiang, Jue; Yan, Jia^*; Jiang, Hong^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(3): 2240-2247.

• Anesthesia
• sevoflurane
• cleft palate
• children
• neurodevelopment

Objective: The purpose of this study was to investigate whether a brief exposure to sevoflurane can lead to adverse neurodevelopmental outcomes in children undergoing palatoplasty. Materials and methods: Young children (less than 2 years old) receiving palatoplasty with sevoflurane anesthesia were recruited. The Bayley Scales of Infant Development-Second Edition (BSID-II) assessment was used to evaluate neurodevelopmental outcomes before and after surgery. The levels of plasma neuron-specific enolase and S-100 beta were also measured. Results: This study enrolled 101 patients and 100 healthy children for analysis. The sevoflurane exposure time of all patients was 46.2 +/- 6.5 minutes. There were no statistically significant differences noted between preoperative and postoperative BSID-II scores, plasma neuron-specific enolase and S-100 beta values. When compared with normal healthy children, there were also no statistically significant differences between patients and normal healthy children at the age of 3-4 years in the BSID-II scores (P>0.05). Conclusions: The data did not show any significant evidence of an association between a brief exposure to sevoflurane during early childhood and adverse neurodevelopmental outcomes in children undergoing palatoplasty.

• 出版日期2018
• 单位上海大学; 上海交通大学