科研之友
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摘要
Receptor 1, composed of two deoxycholic acid moieties appended to a Zn-salophen complex, was prepared, characterized and tested for anion binding by H-1 NMR and UV-vis spectroscopic techniques. While in polar DMSO, 1 is able to bind phosphate (K = similar to 1700 M-1), the addition of water severely diminishes the association. In a 1:9 water-DMSO mixture, the binding constant K is only ca. 20 M-1. Notably, in an aqueous solution of CTABr micelles (CTABr 10 mM, cmc = similar to 1 mM), the zinc-salophen conjugate 1, due to its two non-polar bile-acid moieties, becomes solubilized and, most importantly, it almost completely recovers its binding ability towards phosphate, displaying a remarkable affinity (K = similar to 450 M-1) in water.
- 出版日期2013-7-28
