Bone Regenerative Potential of Modified Biphasic Graft Materials

作者：Khan Rehan; Witek Lukasz; Breit Matthew; Colon Dinely; Tovar Nick; J**** Malvin N; Jimbo Ryo^*; Coelho Paulo G

来源：Implant Dentistry, 2015, 24(2): 149-154.

DOI：10.1097/ID.0000000000000220

• bone grafts
• hydroxyapatite
• tricalcium phosphate
• poly-lactic-co-glycolic acid
• histomorphometry

Purpose: To investigate the bone regenerative effect of polymer and collagen incorporation to synthetic bone graft materials.
Materials and Methods: The bone ingrowth of biphasic graft materials was tested in a rabbit calvaria defect model after chemical characterization: HA/TCP (25%/75%) with collagen, HA/TCP (25%/75%) without collagen, (HA/TCP)/PLGA (85%/15%) with collagen, (HA/TCP)/PLGA (65%/35%) with collagen and a commercially available (HA/TCP)/PLGA (50%/50%) (ReOss T, Intra-Lock International, Boca Raton, FL) was used as control. After 4 and 8 weeks, the retrieved samples were subjected to histomorphometrical analysis.
Results: Histomorphometry presented no significant differences concerning the bone formation between the different groups at both 4 and 8 weeks. Evidently, the (HA/TCP)/PLGA (65%/35%) with collagen presented the least amount of soft tissue incorporation within the defect. The same group possessed higher amounts of bone graft material within the defect throughout the 8-week observation period, whereas the other groups seemed to decrease in volume from 4 to 8 weeks.
Conclusion: Changing the PLGA percentage to 35% within the biphasic graft material seemed to maintain its volume and prevented soft tissue migration, which could be clinically beneficial.

• 出版日期2015-4