A de novo Diels-Alder strategy toward the novel pentacyclic natural product fluostatin C: a concise synthesis of 6-deoxyfluostatin C

作者：Mehta Goverdhan^*; Kumar Y C Sunil; Das Manabendra

来源：Tetrahedron Letters, 2011, 52(27): 3505-3508.

DOI：10.1016/j.tetlet.2011.04.113

• Natural product synthesis
• Cytostatic agents
• Diels-Alder reaction
• Regioselectivity
• Aromatization

A conceptually new Diels-Alder approach, involving a diene moiety grafted on a preformed epoxyquinone platform and a 4-hydroxy-indenone as the dienophile, delivers the pentacyclic framework of fluostatin C in one key step.

• 出版日期2011-7-6