Anthrax and the inflammasome

作者：Moayeri Mahtab^*; Sastalla Inka; Leppla Stephen H

来源：Microbes and Infection, 2012, 14(5): 392-400.

DOI：10.1016/j.micinf.2011.12.005

• Anthrax lethal toxin
• Inflammasome
• Caspase-1
• Nlrp1
• Nlrp1b
• Bacillus anthracis

Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1 beta and IL-18 maturation and a rapid cell death (pyroptosis). This review presents the current understanding of LT-induced activation of Nlrp1 in cells and its consequences for toxin-mediated effects in rodent toxin and spore challenge models. Published by Elsevier Masson SAS on behalf of Institut Pasteur.

• 出版日期2012-5