Development of Novel Thermal Sprayed Antibacterial Coating and Evaluation of Release Properties of Silver Ions

作者：Noda Iwao^*; Miyaji Fumiaki; Ando Yoshiki; Miyamoto Hiroshi; Shimazaki Takafumi; Yonekura Yutaka; Miyazaki Masaki; Mawatari Masaaki; Hotokebuchi Takao

来源：Journal of Biomedical Materials Research Part B: Applied Biomaterials , 2009, 89B(2): 456-465.

DOI：10.1002/jbm.b.31235

• antibacterial
• calcium phosphate coating
• silver ions release
• thermal spraying
• HA-forming ability

Several studies have addressed the use of antibacterial coating to reduce implant-associated infections. In this study, novel silver (Ag)-containing calcium-phosphate (CP) coating technology based on the thermal spraying method was developed. The coating's physical and chemical properties, in vitro antibacterial activity, hydroxyapatite (HA)-forming ability, and release of Ag ions were evaluated. An amorphous structure of the coating was confirmed by X-ray diffraction, and Ag residue in the coating was determined by elementary analysis. The coating showed strong antibacterial activity to methicillin-resistant Staphylococcus aureus in fetal bovine serum (FBS) along with HA-forming ability in simulated body fluid. Therefore, it is expected that the coating would confer antibacterial and bone bonding abilities to the implant surface. Time course release testing of Ag ions from the coating on immersion in FBS showed pronounced Ag release for up to 24 It after immersion, with consistent strong antibacterial activity at the early postoperative stage. In repeated testing, the amount of released Ag ions was about 6500 parts per billion (ppb, mu g/L) for the first release test, after which it gradually decreased. However, retention of significant release of Ag ions after a sixth repeat implies that Ag release from the coating is slow in FBS.

• 出版日期2009-5