Drug attitude and subjective well-being in antipsychotic treatment monotherapy in real-world settings

作者：Balestrieri Matteo^*; Di Sciascio Guido; Isola Miriam; Lomonaco Emanuele; Maso Elisa; Merli Roberto; Calo Salvatore; Bellantuono Cesario

来源：Epidemiologia e Psichiatria Sociale, 2009, 18(2): 114-118.

• drug attitude
• subjective well-being
• antipsychotic drugs
• naturalistic study

Aims - To assess using two well-know scales (DAI-30 and SWN) the drug attitude and subjective well-being of patients treated with haloperidol or second-generation antipsychotics (SGA) in four different Italian communities. Methods - The sample included 145 patients taking five different antipsychotics (APs) in mono-therapy: haloperidol, clozapine, olanzapine, risperidone, quetiapine. A stepwise multiple regression analysis (SMRA) was used to analyse the contribution of different AP treatments and of other predictors to SWN and DAI-30 scores. Results - Univariate analyses showed no differences in DAI-30 and SWN scores across treatments. The SMRA showed that SWN scores were negatively correlated with the severity of the psychoses (BPRS scores), while the DAI-30 scores were negatively correlated with the severity of the psychoses and positively correlated both with the length of drug treatment and with the use of olanzapine. Conclusions - Our study does not confirm a better drug attitude in patients treated with SGA with respect to haloperidol. The only partial exception is the better performance of olanzapine over haloperidol on DAI-30, which could be due to the lower use of anticholinergic drugs during olanzapine treatment. The differences between the SWN and DAI-30 may give good reason for the use of both instruments during AP treatments.

• 出版日期2009-6