Comparison of Outcomes After Use of Biphasic or Monophasic Defibrillators Among Out-of-Hospital Cardiac Arrest Patients A Nationwide Population-Based Observational Study

作者：Tanabe Seizan^*; Yasunaga Hideo; Ogawa Toshio; Koike Soichi; Akahane Manabu; Horiguchi Hiromasa; Hatanaka Tetsuo; Yokota Hiroyuki; Imamura Tomoaki

来源：Circulation. Cardiovascular Quality and Outcomes, 2012, 5(5): 689-696.

DOI：10.1161/CIRCOUTCOMES.112.965319

• cardiopulmonary resuscitation
• defibrillation
• heart arrest
• registries

Background-The use and popularity of the biphasic waveform defibrillator as a replacement for the monophasic waveform defibrillator are increasing, but it is unclear whether this can improve the rate of survival among out-of-hospital cardiac arrest patients. This study aimed to verify the hypothesis that the outcome of out-of-hospital cardiac arrest patients who received defibrillation shock with the biphasic waveform defibrillator was better than that of patients who received defibrillation shock with the monophasic defibrillator.
Methods and Results-This prospective, nationwide, population-based, observational study included 21 172 out-of-hospital cardiac arrest patients with initial ventricular fibrillation or pulseless ventricular tachycardia from January 1, 2005, through December 31, 2007. Defibrillation shock was performed by monophasic defibrillator on 8224 (39%) patients and by biphasic defibrillator on 12 948 (61%) patients. The rate of survival at 1 month with minimal neurological impairment was 11.6% (951/8192) in the monophasic defibrillator group and 12.8% (1653/12928) in the biphasic defibrillator group. Hierarchical logistic regression analysis using a generalized estimation equation showed no significant difference between the biphasic and monophasic groups in 1-month survival with minimal neurological impairment (adjusted odds ratio, 1.07; 95% confidence interval, 0.91-1.26; P=0.42). Confirmatory propensity score analyses showed similar results.
Conclusions-Although monophasic defibrillators are being replaced by biphasic defibrillators, our nationwide population-based observational study failed to demonstrate a statistically significant association between defibrillation waveform and 1-month survival rate with minimal neurological impairment. (Circ Cardiovasc Qual Outcomes. 2012;5:689-696.)

• 出版日期2012-9