A Carbonylation Approach Toward Activation of C-sp2-H and C-sp3-H Bonds: Cu-Catalyzed Regioselective Cross Coupling of Imidazo[1,2-a]pyridines with Methyl Hetarenes

作者：Lei, Sai; Mai, Yingying; Yan, Caijuan; Mao, Jianwen^*; Cao, Hua^*

来源：Organic Letters, 2016, 18(15): 3582-3585.

DOI：10.1021/acs.orglett.6601588

An efficient topper-catalyzed selective cross coupling of imidato [1,2-a]pyridines with methyl hetarenes has been reported. This transformation opened a new route to synthesize the C-3 carbonyl imidazo[1,2-a]pyridine derivative, which is a common structural motif in natural products, and pharmaceuticals. O-18-labeling experiments indicated that the oxygen source of products originated from O-2.

• 出版日期2016-8-5
• 单位广东药科大学