Pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers of different gender

作者：Xu H R^*; Chen W L; Li X N; Liu G Y; Chu N N; Yu C

来源：Pharmazie, 2007, 62(10): 782-784.

DOI：10.1691/ph.2007.10.7501

The study aims to evaluate the pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers and to study the effect of gender on pharmacokinetics of eprosartan. Twenty healthy volunteers (ten men and ten women) were recruited for an open trial and received a single dose of 600 mg eprosartan. Using a validated LC/MS/MS method, plasma and urinary concentrations of eprosartan were defermined. The following pharmacokinetic parameters were elucidated after administration: the area under the plasma concentration versus time curve from 0 to 32 h (AUC(0-32h)) 14818.75 +/- 7312.11 ng center dot h/mL, the area under the plasma concentration versus time curve from 0 to infinite (AUC(0-infinity)) 15081.62 +/- 7379.63 ng center dot h/mL, peak plasma concentration (C-max) 3664.25 +/- 1653.94 ng center dot h/mL, time to C-max (T-max) 1.63 +/- 0.46 h, elimination half-life (t(1/2)) 8.03 +/- 4.04 h, apparent clearance (CL/F) 47.84 +/- 19.21 L/h, apparent volume of distribution of the central compartment (V/F) 537.21 +/- 287.91 L, renal clearance (CLr) 1.33 +/- 0.41 L/h, amount of unchanged eprosartan excreted into urine 18.44 +/- 6.43 mg and fraction of unchanged eprosartan excreted into urine 3.07 +/- 1.07 %. Our results also indicated that no gender differences were observed in the pharmacokinetics of eprosartan in Chinese healthy volunteers.

• 出版日期2007-10
• 单位复旦大学; 上海市徐汇区中心医院