Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

作者：Duarte Neves Joana; de Almeida Luis Pereira; Cavadas Claudia^*

来源：Neurobiology of Disease, 2016, 95: 210-224.

DOI：10.1016/j.nbd.2016.07.022

• Neuropeptide Y
• NPY
• NPY receptors
• Neurodegenerative diseases
• Alzheimer's disease
• Parkinson's disease
• Huntington's disease
• Machado-Joseph disease
• Neurogenesis
• Trophic factors
• Autophagy
• Excitotoxicity
• Neuroinflammation
• Neuroprotection

Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado-Joseph_disease. In this review, we will focus on the roles of NPY in the pathological mechanisms of these disorders, highlighting NPY as a neuroprotective agent, as a neural stem cell proliferative agent, as an agent that increases trophic support, as a stimulator of autophagy and as an inhibitor of excitotoxicity and neuroinflammation. Moreover, the effect of NPY in some clinical manifestations commonly observed in Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado Joseph disease, such as depressive symptoms and body weight loss, are also discussed. In conclusion, this review highlights NPY system as a potential therapeutic target in neurodegenerative diseases.

• 出版日期2016-11