MASH Suite: A User-Friendly and Versatile Software Interface for High-Resolution Mass Spectrometry Data Interpretation and Visualization

作者：Guner Huseyin; Close Patrick L; Cai Wenxuan; Zhang Han; Peng Ying; Gregorich Zachery R; Ge Ying^*

来源：Journal of the American Society for Mass Spectrometry, 2014, 25(3): 464-470.

DOI：10.1007/s13361-013-0789-4

• Top-down mass spectrometry
• Tandem mass spectrometry
• Electron capture dissociation
• Data processing
• Bioinformatics

The rapid advancements in mass spectrometry (MS) instrumentation, particularly in Fourier transform (FT) MS, have made the acquisition of high-resolution and high-accuracy mass measurements routine. However, the software tools for the interpretation of high-resolution MS data are underdeveloped. Although several algorithms for the automatic processing of high-resolution MS data are available, there is still an urgent need for a user-friendly interface with functions that allow users to visualize and validate the computational output. Therefore, we have developed MASH Suite, a user-friendly and versatile software interface for processing high-resolution MS data. MASH Suite contains a wide range of features that allow users to easily navigate through data analysis, visualize complex high-resolution MS data, and manually validate automatically processed results. Furthermore, it provides easy, fast, and reliable interpretation of top-down, middle-down, and bottom-up MS data. MASH Suite is convenient, easily operated, and freely available. It can greatly facilitate the comprehensive interpretation and validation of high-resolution MS data with high accuracy and reliability.

• 出版日期2014-3