A simple one-pot 2-step N-1-alkylation of indoles with alpha-iminoketones toward the expeditious 3-step synthesis of N-1-quinoxaline-indoles

作者：Martinez Ariza Guillermo; Ayaz Muhammad; Hulme Christopher^*

来源：Tetrahedron Letters, 2013, 54(49): 6719-6721.

DOI：10.1016/j.tetlet.2013.09.113

• Multicomponent reaction
• Indole
• Quinoxaline
• alpha-Iminoketone
• Privileged scaffolds

A straightforward procedure for the preparation of N-quinoxaline-indoles is presented. A base-catalyzed one-pot addition of indoles to a preformed alpha-iminoketone proceeds on the N-1 indole and the subsequent adduct undergoes an acid-mediated deprotection of an internal amino nucleophile, intramolecular cyclization, and final oxidation generating N-1-quinoxaline-indoles in good yield.

• 出版日期2013-12-4