Association between 1-h post-load plasma glucose levels and arterial stiffness in normotensive subjects with normal glucose tolerance

作者：Nakagomi Atsushi^*; Sunami Yuko; Okada Sho; Ohno Yuji; Shoji Toshihiro; Fujisawa Takehiko; Kobayashi Yoshio

来源：Diabetes and Vascular Disease Research, 2018, 15(1): 39-45.

DOI：10.1177/1479164117736509

• Arterial stiffness
• atherosclerosis
• brachial-ankle pulse-wave velocity
• oral glucose tolerance test
• 1-h post-load plasma glucose

Objective: To investigate the relationship between 1-h post-load plasma glucose, measured during an oral glucose tolerance test, and arterial stiffness, determined by brachial-ankle pulse-wave velocity, in normotensive subjects with normal glucose tolerance.
Methods: Study subjects were non-industrial workers aged 25-55 years (n = 8381) who underwent a regular health check-up every 5 years. We included only normotensive subjects with normal glucose tolerance based on the American Diabetes Association criteria. Subjects taking medication and having an abnormal ankle-brachial index (<= 1.0 or >= 1.3) were excluded. The final sample comprised 4970 participants (mean age: 38.8 +/- 9.4years; women: n = 2048).
Results: 1-h post-load plasma glucose correlated with brachial-ankle pulse-wave velocity in men (beta = 0.04, p = 0.01), but not women (beta = -0.03, p = 0.13) in multivariate linear regression analysis. We found a significant interaction between 1-h post-load plasma glucose and age in men (p = 0.04); therefore, a subgroup analysis was performed in each 5-year age group. The correlation between 1-h post-load plasma glucose and brachial-ankle pulse-wave velocity was significant in the 55-year-old age group (beta = 0.12, p = 0.01) and neared significant in 45-year-old (beta = 0.08, p = 0.07) and 50-year-old (beta = 0.09, p = 0.07) age groups.
Conclusion: Elevated 1-h post-load plasma glucose levels were associated with arterial stiffness in normotensive, middle-aged men with normal glucose tolerance.

• 出版日期2018-1