Abnormality of the Corpus Callosum in Coalmine Gas Explosion-Related Posttraumatic Stress Disorder

作者：Zhang, Yang; Li, Huabing; Lang, Xu; Zhuo, Chuanjun; Qin, Wen^*; Zhang, Quan

来源：PLos One, 2015, 10(3): e0121095.

DOI：10.1371/journal.pone.0121095

• STRUCTURAL BRAIN ABNORMALITIES
• WHITE-MATTER INTEGRITY
• PTSD
• TRAUMA
• VOLUME
• METAANALYSIS
• CONNECTIVITY
• MALTREATMENT
• DEPRESSION
• PLASTICITY

Abnormal corpus callosum (CC) has been reported in childhood trauma-related posttraumatic stress disorder (PTSD); however, the nature of white matter (WM) integrity alterations in the CC of young adult-onset PTSD patients is unknown. In this study, 14 victims of a coal mine gas explosion with PTSD and 23 matched coal miners without experiencing the coal mine explosion were enrolled. The differences in fractional anisotropy (FA) within 7 sub-regions of the CC were compared between the two groups. Compared to the controls, PTSD coal miners exhibited significantly reduced FA values in the anterior sub-regions of the CC (P < 0.05, Bonferroni-corrected), which mainly interconnect the bilateral frontal cortices. Our findings indicated that the anterior part of the CC was more severely impaired than the posterior part in young adult-onset PTSD, which suggested the patterns of CC impairment may depend on the developmental stage of the structure when the PTSD occurs.

• 出版日期2015-3-23
• 单位天津医科大学