Analysis of Plasma Multiplex Cytokines for Children With Febrile Seizures and Severe Acute Encephalitis

作者：Hu Mei Hua; Huang Go Shine; Wu Chang Teng; Lin Jainn Jim; Hsia Shao Hsuan; Wang Huei Shyong; Lin Kuang Lin^*

来源：Journal of Child Neurology, 2014, 29(2): 182-186.

DOI：10.1177/0883073813488829

• cytokine
• febrile seizures
• severe acute encephalitis
• interleukin-6
• inflammation

We investigated the plasma cytokine profiles of children with febrile seizures or severe acute encephalitis using multiplex cytometry to evaluate the role of cytokines in these diseases. Interleukin-6, -10, -12p70, -17A, -2, -4, -5, -9, -13, -22, and -1, interferon-, and tumor necrosis factor- were measured in the plasma from children with febrile seizures (n = 9) or severe acute encephalitis (n = 21). In multivariate analysis, interleukin-6 was significantly increased in the plasma of the febrile seizure patients compared to those with severe acute encephalitis, suggesting that interleukin-6 is activated during the acute stage of a febrile seizure. A lower plasma interleukin-6 concentration was significantly associated with severe acute encephalitis. The cytokine network may be deregulated in severe acute encephalitis via the persistence of an uncontrolled inflammatory state in the brain.

• 单位
  长春大学