Anti-angiogenic activity of julibroside J(8), a natural product isolated from Albizia julibrissin

作者：Hua Hui; Feng Lei; Zhang Xiao ping; Zhang Lian fen; Jin Jian^*

来源：Phytomedicine, 2009, 16(8): 703-711.

DOI：10.1016/j.phymed.2009.01.002

• Julibroside J(8)
• Ginsenoside Rg(3)
• Human microvascular endothelial cell
• Angiogenesis

Purpose: The purpose of this study was to investigate the anti-angiogenic properties of julibroside J(8), a triterpenoid saponin isolated from Albizia julibrissin.
Methods: In the presence of juliborside J(8) the growth of human microvascular endothelial cells (HMEC-1), four human tumor cell lines, and a normal cell line (MRC-5) was evaluated by MTT assay. The in vivo anti-angiogenic effect of julibroside J(8) was evaluated on a chorioallantoic membrane (CAM) and in transplanted colon carcinoma cells in a nude mice neovascularisation model.
Results: Treatment with 0.5-4 mu g/ml julibroside J(8) resulted in dose-dependent inhibition of growth, migration, and tube formation in HMEC-1 cells; julibroside J(8) also inhibited the formation of microvessels on CAM at a concentration of 10-50 mu g/egg and reduced vessel density within tumor at a concentration of 0.5-3 mg/kg.
Conclusions: Julibroside J(8) may be a potent anti-angiogenetic and cytotoxic drug; further investigation is warranted.

• 出版日期2009-8
• 单位江南大学