Disrupted Th1/Th2 balance in patients with rheumatoid arthritis (RA)

作者：He, Chunyan; Feng, Ping; Su, Honghong; Gu, Aiping; Yan, Zhaowei^*; Zhu, Xueming^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(2): 1233-1242.

• Cytokines
• rheumatoid arthritis
• microparticles

The imbalance of Th1/Th2 polarization in patients with Rheumatoid Arthritis (RA) and the effect of Mps derived from plasma of RA patients were reported in this study. It was found that the percentage of IFN-gamma(+)CD4(+) T cell in peripheral blood and Th1/Th2 ratio were significantly increased in RA patients. Sera from patients with RA promoted Th1/Th2 balance biased towards Th1 by enhancing Th1-type cytokine (IFN-gamma and TNF-alpha) expression and reducing Th2-type (IL-6 and IL10) cytokine expression, respectively, in a dose-dependent manner. Conversely, Mps derived from RA patients disrupted the balance of Th1/Th2 by decreasing TNF-alpha expression and increasing IL-6 and IL-10 expression. The results illustrated RA patients were characterized by a disruption of Th1/Th2 balance towards Th1. Sera from RA patients promoted a Th1/Th2 balance bias towards Th1, which could be counteracted by Mps derived from RA patients disrupting the balance of Th1/Th2 in an opposing manner.

• 出版日期2017
• 单位苏州大学