Asynchronous Onset of Clinical Disease in BSE-Infected Macaques

作者:Montag Judith; Schulz Schaeffer Walter; Schrod Annette; Hunsmann Gerhard; Motzkus Dirk*
来源:Emerging Infectious Diseases, 2013, 19(7): 1125-1127.
DOI:10.3201/eid1907.120438

摘要

To estimate the effect of the variability of prion disease onset on primary bovine spongiform encephalopathy transmission to humans, we studied 6 cynomolgus macaques. The preclinical incubation period was significantly prolonged in 2 animals, implying that onset of variant Creutzfeldt-Jacob disease in humans could be more diverse than previously expected.

  • 出版日期2013-7