Amyloid-beta induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease

作者：Um Ji Won; Strittmatter Stephen M^*

来源：Prion, 2013, 7(1): 37-41.

DOI：10.4161/pri.22212

• prion
• Fyn kinase
• Alzheimer disease
• Prp(C)
• cellular prion protein

Alzheimer disease (AD) is the most prevalent cause of dementia. Amyloid-beta (A beta) oligomers are potent synaptotoxins thought to mediate AD-related phenotypes. Cellular prion protein (PrPC) has been identified as a high-affinity receptor for A beta oligomers. Herein, we review the functional consequences of A beta oligomer binding to PrPC on the neuronal surface. We highlight recent evidence that Fyn kinase mediates signal transduction downstream of the PrPC-A beta oligomer complex. These studies suggest that PrPC has a central role in AD pathogenesis and may provide a target for therapeutic intervention in AD.

• 出版日期2013-2