Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis

作者：Khan Anwar Jamal; Husain Qayyum; Choudhuri Gourdas; Parmar Devendra^*

来源：Drug and Alcohol Dependence, 2010, 109(1-3): 190-197.

DOI：10.1016/j.drugalcdep.2010.01.010

• Alcoholic liver cirrhosis
• Alcohol dehydrogenase
• Polymorphism
• Risk
• Interaction

The association of polymorphism of alcohol dehydrogenase (ADH) and its interaction with genes involved in the generation and detoxification of free radicals such as cytochrome P4502E1 (CYP2E1) and glutathione S-transferases M1 (GSTM1) were studied with alcoholic liver cirrhosis. The study included 175 alcoholic cirrhotic patients, 140 non-alcoholic cirrhotic patients, 255 non-alcoholic controls and 140 alcoholic controls. Our data revealed that the ADH1C*11 genotype exhibited significant association with alcoholic liver cirrhosis while ADH1B genotypes did not show any significant association. A much higher risk to alcoholic liver cirrhosis was observed in patients carrying a combination of wild genotypes of ADH1C (ADH1C11) and variant genotype of ADH1B (ADH1B*2/.2) or CYP2E1 (CYP2E1*5B) or null genotype of GSTM1. Our data suggest a role for the interaction amongst the genes involved in metabolizing alcohol and in generating and detoxifying free radicals with susceptibility to alcoholic liver cirrhosis.

• 出版日期2010-6-1
• 单位河北医科大学