Ultrasound-assisted synthesis and preliminary bioactivity of novel 2H-1,2,4-thiadiazolo[2,3-a]pyrimidine derivatives containing fluorine

作者：Wang, Mao Rong; Jiang, Lin^*; Zhou, Shao Fang; Zhang, Ze Yuan; Ji, Zeng Chen

来源：Chinese Chemical Letters, 2012, 23(5): 561-564.

DOI：10.1016/j.cclet.2012.03.005

• 2H-1,2,4-Thiadiazolo[2,3-a]pyrimidine
• Synthesis
• Ultrasound
• Bioactivity

Eight novel 5,7-disubstituted-2-{5-methyl-3-(4-trifluoromethylphenyl)isoxazol-4-ylcarbonylimin} -2H-1,2,4-thiadiazolo[2,3-a]pyrimidines were synthesized by multi-step reactions in yields 68-85%. Reactions were carried out either by ultrasound irradiation or conventional method, and found it was faster and more efficient under ultrasonic irradiation. Preliminary herbicidal activities against Echinochloa crus-galli, Digitaria sanguinalis and Chenopodium serotinum were also evaluated by flat-utensil method, and the results indicated that the target compounds exhibited significant activities, some were even higher than the control herbicide.

• 出版日期2012-5
• 单位山东农业大学