Higher augmentation index is associated with tension-type headache and migraine in middle-aged/older humans with obesity

作者：Kalil Graziela Z; Recober Ana; Hoang Tienor Ann; Zimmerman Miriam Bridget; Haynes William G; Pierce Gary L^*

来源：Obesity, 2016, 24(4): 865-870.

DOI：10.1002/oby.21414

ObjectiveObesity is a major risk factor for chronic daily headaches, including migraine and tension-type headache (TTH). Although migraine is associated with increased risk of cardiovascular diseases (CVD), a relation between TTH and CVD risk has not been established. It was hypothesized that higher carotid-femoral pulse wave velocity (CFPWV) and augmentation index (AI), measures of aortic stiffness and pressure wave reflection, respectively, and biomarkers of CVD risk, would be higher among adults with obesity and migraine or TTH compared with those with no headache.
MethodsAdults with obesity (n=93; body mass index30 kg/m(2)) who were between 40 and 75 years old with at least one additional CVD risk factor were enrolled. Subjects had CFPWV and AI assessed and a complete neurological exam for diagnosis of headache in the past 12 months.
ResultsAdults with obesity and TTH (P=0.018), but not migraine (P=0.29), had significantly higher AI compared with those with no headache. When both CFPWV and AI were considered in a logistic regression model with migraine or TTH, only AI was associated with TTH (P=0.008) and migraine (P=0.032) but could not distinguish between the two headache phenotypes.
ConclusionsIncreased aortic AI but not stiffness is associated with TTH and migraine among middle-aged/older adults with obesity and high CVD risk.

• 出版日期2016-4