Hyaluronic acid-supported combination of water insoluble immunostimulatory compounds for anti-cancer immunotherapy

作者：Shin Woo Jung; Noh Hyun Jong; Noh Young Woock; Kim Sohyun; Um Soong Ho; Lim Yong Taik^*

来源：Carbohydrate Polymers, 2017, 155: 1-10.

DOI：10.1016/j.carbpol.2016.08.040

• Cancer immunotherapy
• Powder-form adjuvant
• Immunostimulation
• Hyaluronic acid
• Cellular immunity

A novel powder-form combination adjuvant system containing two immunostimulatory compounds was firstly developed and evaluated as a therapeutic intervention for cancer immunotherapy. With the help of hyaluronic acid (HA), water insoluble monophosphoryl lipid A (MPL), QS21 and imiquimod (R837), could be easily dispersed in aqueous solution and lyophilized as powder-form, which have an advantage in room-temperature storage stability compared with those conventional liquid formulation that requires cold storage. Two kinds of HA-based combination vaccine adjuvants (HA/MPL/QS21, HMQ and HA/MPL/R837, HMR) contributed to the increase of both humoral and cellular immunity, which is very important for efficient cancer immunotherapy. Through the challenge experiments in EG7-OVA (mouse lymphoma-expressing OVA) tumor-bearing mice model, we found out that the immunostimulatory effects of HMQ and HMR were successful in the inhibition of tumor proliferation. Taken together, both HA-based powder-form combination adjuvant systems are expected to be used as potent prophylactic and therapeutic cancer vaccine.

• 出版日期2017-1-2