Promoter melting by an alternative sigma, one base at a time

作者：Darst Seth A^*; Feklistov Andrey; Gross Carol A

来源：Nature Structural & Molecular Biology, 2014, 21(4): 350-351.

DOI：10.1038/nsmb.2798

Housekeeping sigma factors are initiation factors for the bacterial RNA polymerase at most promoters, whereas alternative sigma s direct focused responses to specific environmental conditions. Structural and functional analysis of an alternative sigma complexed with its cognate -10 motif elucidates the mechanism for initiation of strand opening, highlighting two critical properties: why alternative sigma s, compared to housekeeping sigma s, recognize so few promoters and how their promoter-recognition strategy was diversified during evolution.

• 出版日期2014-4