Auroside, a Xylosyl-sterol, and Patusterol A and B, two Hydroxylated Sterols, from two Soft Corals Eleutherobia aurea and Lobophytum patulum

作者：Yeffet Dina; Rudi Amira; Ketzinel Sharon; Benayahu Yehuda; Kashman Yoel^*

来源：Natural Product Communications, 2010, 5(2): 205-210.

DOI：10.1177/1934578x1000500207

• Eleutherobia aurea
• Lobophytum patulum
• soft corals
• sterols
• NMR

A new sterol glycoside, auroside (1) and two new hydroxylated sterols, patusterol A and B (2, 3) have been isolated from the South African soft coral Eleutherobia aurea and from the Kenyan soft coral Lobophytum patulum. The structure elucidation was achieved from extensive 1D- and 2D- NMR and MS data, and in the case of auroside also by chemical reactions. In addition, from Lobophytum patulum, was also isolated a known nitrogen containing compound (Z)-N-[2-(4-hydroxyphenyl)ethyl]-3-methyldodec-2-enamide, and from Eleutherobia aurea several, earlier reported, diterpenoids. Compound 2 was found to be toxic to brine shrimp embryos with an LC(50) value of 2.30 mu M.

• 出版日期2010-2