A Novel Straightforward Synthesis of 2,4-Disubstituted-1,3,5-triazines via Aerobic Copper-Catalyzed Cyclization of Amidines with DMF

作者：Xu, Xiaowen; Zhang, Min^*; Jiang, Huanfeng; Zheng, Jia; Li, Yiqun

来源：Organic Letters, 2014, 16(13): 3540-3543.

DOI：10.1021/ol501493h

• Copper-Catalyzed
• Cyclization
• Amidines

A novel straightforward synthesis of both symmetrical and unsymmetrical 2,4-disubstituted-1,3,5-triazines via aerobic copper-catalyzed cyclization of amidines with DMF as a one-carbon synthon has been developed. The presented method allows synthesizing the products that are currently inaccessible or challenging to prepare with the advantages of operational simplicity, broad substrate scope, and no need for prefunctionalized reagents, making it a highly practical approach to access various 2,4-disubstituted-1,3,5-triazines.

• 出版日期2014-7-4
• 单位华南理工大学; 暨南大学