Age-related Disparity: Breast Cancer in the Elderly

作者：Gosain Rahul; Pollock YaoYao; Jain Dharamvir

来源：Current Oncology Reports, 2016, 18(11): 69.

DOI：10.1007/s11912-016-0551-8

• Breast cancer
• Women
• Elderly
• Older
• Age
• Comorbidities
• Geriatric assessment
• Adjuvant therapy
• Neoadjuvant
• Endocrine therapy
• Aromatase inhibitor
• Chemotherapy
• Trastuzumab
• Surgery
• Lumpectomy
• Radiation therapy
• Supportive care
• Quality of life

Aging poses an unique opportunity to study cancer biology and treatment in older adults. Breast cancer is often studied in young women; however, much investigation remains to be done on breast cancer in our expanding elderly population. Diagnostic and management strategies applicable to younger patients cannot be empirically used to manage older breast cancer patients. Lack of evidence-based data continues to be the major impediment toward delivery of personalized cancer care to elderly breast cancer patients. This article reviews the relevant literature on management of curable breast cancer in the elderly, the role of geriatric assessment, complex treatment decision making within the context of patient's expected life expectancy, comorbidities, physical function, socioeconomic status, barriers to health care delivery, goals of treatment, and therapy-related side effects. Continuing efforts for enrolling elderly breast cancer patients in contemporary clinical trials, and thus improving age-appropriate care, are emphasized.

• 出版日期2016-11