Association between Cellular Immune Activation, Target Cell Frequency, and Risk of Human Immunodeficiency Virus Type 1 Superinfection

作者：Blish Catherine A^*; Dogan Ozge C; Jaoko Walter; McClelland R Scott; Mandaliya Kishorchandra; Odem Davis Katherine; Richardson Barbra A; Overbaugh Julie

来源：Journal of Virology, 2014, 88(10): 5894-5899.

DOI：10.1128/JVI.00187-14

We performed a case-control study of women at risk of HIV-1 superinfection to understand the relationship between immune activation and HIV-1 acquisition. An increase in the frequency of HIV-1 target cells, but not in other markers of T cell activation, was associated with a 1.7-fold increase in the odds of superinfection. This suggests that HIV-1 acquisition risk is influenced more by the frequency of target cells than by the generalized level of immune activation.

• 出版日期2014-5