Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-gamma in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis

作者：Imaizumi T; Tanaka H^*; Tajima A; Tsuruga K; Oki E; Sashinami H; Matsumiya T; Yoshida H; Inoue I; Ito E

来源：Lupus, 2010, 19(7): 830-836.

DOI：10.1177/0961203309360540

• IFN-gamma
• IFN regulatory factor 7
• lupus nephritis
• mesangial cells
• retinoic acid-inducible gene-I

Interferon-gamma is a potent Th1-type cytokine and a key molecule in the pathogenesis of autoimmune diseases including lupus nephritis. Retinoic acid-inducible gene-I is a putative RNA helicase that plays an important role in immune and inflammatory reactions. We previously demonstrated the increased expression of the retinoic acid-inducible gene-I protein in the kidney tissue of patients with lupus nephritis, and the presence of a significant amount of retinoic acid-inducible gene-I mRNA in the urinary sediment of patients with this inflammatory renal disease. In the present study, interferon-gamma was found to induce the expression of retinoic acid-inducible gene-I in human mesangial cells in culture. Knockdown of retinoic acid-inducible gene-I inhibited the interferon-gamma-induced upregulation of interferon regulatory factor 7, a transcriptional factor involved in immune and inflammatory reactions. These findings suggest that retinoic acid-inducible gene-I produced by mesangial cells may be involved in the pathogenesis of lupus nephritis. Lupus (2010) 19, 830-836.

• 出版日期2010-6