Systemic effects of whole-body cooling to 35 degrees C, 33.5 degrees C, and 30 degrees C in a piglet model of perinatal asphyxia: implications for therapeutic hypothermia

作者：Kerenyi Aron; Kelen Dorottya; Faulkner Stuart D; Bainbridge Alan; Chandrasekaran Manigandan; Cady Ernest B; Golay Xavier; Robertson Nicola J^*

来源：Pediatric Research, 2012, 71(5): 573-582.

DOI：10.1038/pr.2012.8

INTRODUCTION: The precise temperature for optimal neuroprotection in infants with neonatal encephalopathy is unclear. Our aim was to assess systemic effects of whole-body cooling to 35 degrees C, 33.5 degrees C, and 30 degrees C in a piglet model of perinatal asphyxia.
METHODS: Twenty-eight anesthetized male piglets aged <24 h underwent hypoxia-ischemia (HI) and were randomized to normothermia or cooling to rectal temperature (Trec) 35 degrees C, 33.5 degrees C, or 30 degrees C during 2-26 h after insult (n = 7 in each group). HR, MABP, and Trec were recorded continuously.
RESULTS: Five animals cooled to 30 degrees C had fatal cardiac arrests. During 30 degrees C cooling, heart rate (HR) was lower vs. normothermia (P < 0.001). Although mean arterial blood pressure (MABP) did not vary between groups, more fluid boluses were needed at 30 degrees C than at normothermia (P < 0.02); dopamine use was higher at 30 degrees C than at normothermia or 35 degrees C (P = 0.005 and P =- 0.02, respectively). Base deficit was increased at 30 degrees C at 12, 24, and 36h vs. all other groups (P < 0.05), pH was acidotic at 36h vs. normothermia (P = 0.04), and blood glucose was higher for the 30 degrees C group at 12 h vs. the normothermia and 35 degrees C groups (P < 0.05). Potassium was lower at 12 h in the 30 degrees C group vs. the 33.5 degrees C and 35 degrees C groups. There was no difference in cortisol level between groups.
DISCUSSION: Cooling to 30 degrees C led to metabolic derangement and more cardiac arrests and deaths than cooling to 33.5 degrees C or 35 degrees C. Inadvertent overcooling should be avoided.

• 出版日期2012-5